Case Reports in Clinical Practice 2017. 2(4):103-106.

Unusual Presentation of Wells Syndrome: A Case Report
safoura shakoei, maryam Ranjbar, Masoumeh Rohani Nasab, Azita Nikoo


Wells syndrome is an uncommon disease that typically presents as edematous erythematous plaques, usually preceded by burning or itching of the skin. Histopathological examination shows dense dermal eosinophilic infiltrates in an edematous dermis at the acute phase of lesions. Some of the identified triggering factors include infection, arthropod bites, hematological malignancies, thimerosal containing vaccines and drugs such as penicillin, lincomycin, tetracycline, minocycline and ampicillin. Here we describe a case of Wells syndrome in a 75-year-old woman that its outstanding feature was its large size. Although this case was resistant to our treatment, the condition improved spontaneously after several weeks without administering any other alternative treatments. On the other hand, despite its large size, this case had no identifiable trigger


Wells syndrome; Eosinophilic cellulitis; Eosinophili

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Wells GC. Recurrent granulomatous dermatitis with eosinophilia. Trans St Johns Hosp Dermatol Soc 1971; 57(1): 46-56.

Karabudak O, Dogan B, Taskapan O, Harmanyeri Y. Eosinophilic cellulitis presented with semicircular pattern. J Dermatol 2006; 33(11): 798-801.

Heelan K, Ryan JF, Shear NH, Egan CA. Wells syndrome (eosinophilic cellulitis): Proposed diagnostic criteria and a literature review of the drug-induced variant. J Dermatol Case Rep 2013; 7(4): 113-20.

Sinno H, Lacroix JP, Lee J, Izadpanah A, Borsuk R, Watters K, et al. Diagnosis and management of eosinophilic cellulitis (Wells' syndrome): A case series and literature review. Can J Plast Surg 2012; 20(2): 91-7.

Nacaroglu HT, Celegen M, Karkiner CS, Gunay I, Diniz G, Can D. Eosinophilic cellulitis (Wells' syndrome) caused by a temporary henna tattoo. Postepy Dermatol Alergol 2014; 31(5): 322-4.

Thomas L, Fatah S, Nagarajan S, Natarajan S. Eosinophilic annular erythema: Successful response to ultraviolet B therapy. Clin Exp Dermatol 2015; 40(8): 883-6.

Canonne D, Dubost-Brama A, Segard M, Piette F, Delaporte E. Wells' syndrome associated with recurrent giardiasis. Br J Dermatol 2000; 143(2): 425-7.

Rajpara A, Liolios A, Fraga G, Blackmon J. Recurrent paraneoplastic wells syndrome in a patient with metastatic renal cell cancer. Dermatol Online J 2014; 20(6).

Simpson JK, Patalay R, Francis N, Roberts N. Influenza vaccination as a novel trigger of wells syndrome in a child. Pediatr Dermatol 2015; 32(4): e171-e172.

Thomas J, Begum CZ, Tamilarasi S. Well's syndrome in a child: A rare case report. Indian J Paediatr Dermatol 2015; 16(2): 90-2.


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