Tehran University of Medical Sciences Case Reports in Clinical Practice 2538-2683 9 6 2025 07 01 253 256 Apoorva Suran Department of Endocrinology, Peoples Medical College and Research Centre, Bhopal, M.P, India. Jaideep Khare Department of Endocrinology, Peoples Medical College and Research Centre, Bhopal, M.P, India. 2025 04 07 2025 05 17 Alström syndrome is a rare multi-system congenital disorder with varied phenotypic presentations, including obesity, early-onset blindness, hearing loss, and various cardiac and renal manifestations. We discuss a case of a young male who presented with Type 2 Diabetes Mellitus (T2DM) and dyslipidemia, with a history of lindness and hearing loss since childhood. His family history was significant, with three prior sibling deaths. Genetic evaluation confirmed the diagnosis of Alström syndrome. He did not have obesity or any cardiovascular complications. The rest of the systemic examination and blood work were normal. This case is noteworthy as it represents one of the few variants of Alström syndrome without obesity. Early diagnosis and management are crucial for these patients to prevent avoidable complications and improve their quality of life. https://crcp.tums.ac.ir/index.php/crcp/article/view/1024 https://crcp.tums.ac.ir/index.php/crcp/article/download/1024/696