Tehran University of Medical Sciences Case Reports in Clinical Practice 2538-2683 10 2 2025 10 15 64 68 Mohammad Hossain Validad Department of Ophthalmology, Faculty of Medicine, University of Zahedan, Zahedan, Iran. Alireza Salimi-Khorashad Department of Parasitology and Mycology, Infectious Diseases and Tropical Medicine Research Center, Research Institute of Cellular and Molecular Sciences in Infectious Diseases, Zahedan University of Medical Sciences, Zahedan, Iran. Fateme Rezaei Kahkhaei Department of Surgical Technology,School of Nursing and Midwifery, Zahedan University of Medical Sciences, Zahedan, Iran. 2025 07 06 2025 09 08 Amebic keratitis is a rare but serious corneal infection that is occasionally seen in contact lens wearers. In the early stages, the disease may be mistaken for bacterial keratitis due to corneal inflammation and a reduced visual field, which can delay diagnosis and treatment. In this case report, we present a young female who exhibited symptoms of a corneal ulcer associated with contact lens use and was initially treated for bacterial keratitis. Upon further evaluation, the diagnosis of Naegleria amebic keratitis was confirmed.   https://crcp.tums.ac.ir/index.php/crcp/article/view/1067 https://crcp.tums.ac.ir/index.php/crcp/article/download/1067/716