Tehran University of Medical Sciences Case Reports in Clinical Practice 2538-2683 10 3 2025 12 09 114 117 Zahra Heydari Pediatric Hematology and Oncology Department, Bahrami Children’s Hospital, Tehran University of Medical Sciences, Tehran, Iran. Mohammad Kaji Yazdi Pediatric Hematology and Oncology Department, Bahrami Children’s Hospital, Tehran University of Medical Sciences, Tehran, Iran. 2025 08 17 2025 09 27 Burkitt’s lymphoma (BL) emerges as the most prevalent subtype of non-Hodgkin lymphoma (NHL) in pediatric populations. Several studies have demonstrated a connection between certain viral infections and Burkitt’s lymphoma, suggesting a potential correlation between these factors. Although BL typically presents with lymph node involvement, neurological manifestations are quite rare. In this report, we detail the case of a 13-year-old male patient who initially presented with a varicella zoster infection, accompanied by neurological symptoms consistent with Guillain-Barré syndrome (GBS), and subsequently developed a substantial submandibular mass. Diagnostic imaging, along with biopsy, confirmed a diagnosis of high-grade B-cell lymphoma consistent with BL. https://crcp.tums.ac.ir/index.php/crcp/article/view/1090 https://crcp.tums.ac.ir/index.php/crcp/article/download/1090/729