Tehran University of Medical Sciences Case Reports in Clinical Practice 2538-2683 2 2 2017 10 10 37 41 EN Mohammadreza Salehi Department of Infectious Diseases, School of Medicine, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran. Fatemeh Talebi Department of Infectious Diseases, School of Medicine, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran. Alireza Ghanadan Department of Pathology, School of Medicine, Cancer Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran. Niloofar Ayoobi Yazdi Department of Radiology, School of Medicine, Advanced Diagnostic and Interventional Radiology Research Center, Tehran University of Medical Sciences, Tehran, Iran. 2017 05 14 2017 08 22 Lymphoma is the most common malignancy originating from hematopoietic systems. Diverse biological and clinical manifestations of non-Hodgkin lymphoma have been recognized. As an unusual type of non-Hodgkin lymphoma is Burkitt lymphoma. The variability of the initial presentation is not unusual. We present a 15-year-old boy with generalized abdominal pain, fever. He had massive orange pleural effusion and ascites. There were peritoneal seeding and omentum thickening in abdominal computed tomography scan. Pathological investigations of the peritoneal biopsy revealed B-cell lymphoma (starry sky in pathology). The clinical presentation of sporadic Burkitt lymphoma could mimic some other diseases. Therefore, the clinicians should consider Burkitt lymphoma between the multiple differential diagnoses. In the case of peritoneal involvement, its differential diagnosis could be usually, peritoneal carcinomatosis, malignant peritoneal mesothelioma, and tuberculous peritonitis. https://crcp.tums.ac.ir/index.php/crcp/article/view/114 https://crcp.tums.ac.ir/index.php/crcp/article/download/114/74