Tehran University of Medical Sciences Case Reports in Clinical Practice 2538-2683 10 4 2026 04 18 176 180 Shirin Assar Clinical Research Development Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran. Mehran Pournazari Clinical Research Development Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran. Dena Mohamadzadeh Clinical Research Development Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran. 2025 11 19 2025 12 10 Peripheral neuropathy is rarely the initial presentation of lymphoma. Acute inflammatory demyelinating sensorimotor neuropathy, meeting the diagnostic criteria of Guillain-Barré syndrome, might be associated with Hodgkin’s lymphoma. A 33-yearold woman presented with dyspnea, generalized lymphadenopathy, acute-onset progressive ascending muscle weakness of the lower extremities, and acute bilateral uveitis. EMG-NCV confirmed acute inflammatory demyelinating polyneuropathy. Malignant lymphoma was suspected. A core needle biopsy of the left axillary lymph node was performed and revealed the classic type of Hodgkin’s lymphoma. The ABVD regimen was administered along with five consecutive sessions of plasmapheresis. The neurological signs and symptoms improved gradually. In conclusion, acute inflammatory demyelinating polyneuropathy mimicking Guillain-Barré syndrome might be associated with HL and precede the diagnosis of lymphoma. Therefore, clinicians need to be aware of the neurological manifestations of lymphoma for appropriate diagnosis and treatment. https://crcp.tums.ac.ir/index.php/crcp/article/view/1140 https://crcp.tums.ac.ir/index.php/crcp/article/download/1140/741