Tehran University of Medical Sciences Case Reports in Clinical Practice 2538-2683 11 2 2026 08 29 82 85 Somayeh Mirbagheri Emergency Medicine Department, Ganji Hospital Complex, Bushehr University of Medical Sciences, Bushehr, Iran Kheirolnesa Hajizadeh Ahmari Cardiology Department, Ganji Hospital Complex, Bushehr University of Medical Sciences, Bushehr, Iran 2026 06 16 2026 06 29 Electrical storm and refractory ventricular fibrillation (VF) are rare but catastrophic complications of acute myocardial infarction (AMI) and are associated with high mortality despite adherence to advanced cardiac life support protocols. We report a 48‑year‑old man with a history of ischemic heart disease, percutaneous coronary intervention, and hypertension who presented with severe exertion‑induced chest pain and was diagnosed with acute inferior ST‑elevation myocardial infarction. During monitoring, he developed recurrent malignant ventricular arrhythmias progressing to refractory VF despite repeated biphasic defibrillation and antiarrhythmic therapy. Sequential defibrillation with 200‑J shocks was performed with procedural sedation and analgesia before each attempt, with a cumulative delivered energy of approximately 4000 J. Intravenous amiodarone, lidocaine, and magnesium sulfate were administered, and thrombolytic therapy with reteplase was initiated. Persistent VF ultimately required dual sequential defibrillation, which successfully restored a stable sinus rhythm. The patient was transferred for urgent coronary angiography and was discharged three days later in stable clinical condition. This case highlights the potential role of dual sequential defibrillation as a rescue strategy in refractory ventricular fibrillation complicating acute myocardial infarction. https://crcp.tums.ac.ir/index.php/crcp/article/view/1207 https://crcp.tums.ac.ir/index.php/crcp/article/download/1207/784