Tehran University of Medical Sciences Case Reports in Clinical Practice 2538-2683 3 2 2018 12 24 42 43 EN Reza Bidaki Department of Psychiatry, Research Center of Addiction and Behavioral Sciences, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. AND Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Farzaneh Dehghani Department of Psychiatry, Research Center of Addiction and Behavioral Sciences, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. 2018 02 07 2018 07 22 Heterogeneous findings have been reported regarding the effects of anti-depressive drugs over platelet counts. Among antidepressant drugs, Selective Serotonin Reuptake Inhibitors (SSRIs) has been shown to reduce platelet aggregation. We report a patient with reduction in her platelets counts as well as bruising occurrence following three days of receiving sertraline. In patients with a history of bleeding, ITP or familial ITP, their psychiatric treatment and prescribing SSRI should be done with caution.     https://crcp.tums.ac.ir/index.php/crcp/article/view/184 https://crcp.tums.ac.ir/index.php/crcp/article/download/184/280