Tehran University of Medical Sciences Case Reports in Clinical Practice 2538-2683 3 3 2019 01 15 86 89 EN Sara Abolghasemi Infectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Shahnaz Sali Infectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Manijeh Roohi Infectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Narjes Shokatpour Department of Microbiology, Faculty of Biological Sciences, Shahid Beheshti University, Tehran, Iran. 2018 08 07 2018 10 23 Skin necrosis is considered as a rare but severe complication of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) injections. Symptoms comprise intense pain around the injection site, evolving into erythema, livedoid violaceous patch, hemorrhagic patch, and eventually necrosis of the skin. The pathogenesis is not fully clear. However, it is presumed that damage to an end artery and the cytotoxic effects of the drug are main causes. We present a patient who developed skin necrosis after ketorolac intravascular adminisration for the treatment of renal colic. To the bes of our knowledge, this is the frs report describing skin necrosis after ketorolac intravascular injection. https://crcp.tums.ac.ir/index.php/crcp/article/view/209 https://crcp.tums.ac.ir/index.php/crcp/article/download/209/274