Tehran University of Medical Sciences Case Reports in Clinical Practice 2538-2683 3 4 2019 04 17 113 117 Rahim Badrfam Department of Psychiatry, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran. Atefeh Zandifar Department of Psychiatry, Imam Hossein Hospital, Alborz University of Medical Sciences, Karaj, Iran. Seyed Ali Ahmadi Abhari Department of Psychiatry, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran. 2018 09 14 2018 10 16 In the last couple of years, with the advancement of imaging methods, the diagnosis of gray matter heterotopia has been more promising. Gray matter heterotopia is a rare disorder in the general population, but recent attention to its psychiatric aspects encouraged us to introduce a patient with a form of gray matter heterotopia, who suffers from the anatomical abnormalities with a variety of psychiatric disorders. Our patient is a 25-year-old woman, who presented a variety of organogenesis disorders such as imperforate anus and rectovaginal fistula with the presence of gray matter heterotopia and history of refractory mood and psychotic disorders during 9 past years. Because of the various clinical manifestations of the disease, syndromic attention to this disease seems to be helpful in diagnosing and treating its various aspects. https://crcp.tums.ac.ir/index.php/crcp/article/view/221 https://crcp.tums.ac.ir/index.php/crcp/article/download/221/304