Tehran University of Medical Sciences Case Reports in Clinical Practice 2538-2683 3 4 2019 04 17 128 131 Behshad Pazooki Department of Internal Medicine, School of Medicine, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran. Hanieh Radkhah Department of Internal Medicine, School of Medicine, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran. Alborz Sherafati Department of Cardiology, School of Medicine, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran. 2018 09 24 2018 12 17 During the recent years, paradoxical embolism and Patent Foramen Ovale (PFO) have drawn great attention because of their strong correlation with cryptogenic stroke in young patients. The coexistence of pulmonary and paradoxical embolism is even rarer. Awareness of this complication with prompt recognition and treatment could prevent significant disability and death. We presented a 51-year-old man with evidence of concomitant pulmonary embolism and overload due to Pulmonary Thromboembolism and stroke, which suggests the presence of Patent Foramen Ovale. He was successfully treated with anticoagulation and PTO closure was performed. https://crcp.tums.ac.ir/index.php/crcp/article/view/224 https://crcp.tums.ac.ir/index.php/crcp/article/download/224/308