Tehran University of Medical Sciences Case Reports in Clinical Practice 2538-2683 4 4 2020 04 30 125 127 Mahnaz Pejman Sani Department of Internal Medicine, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran. Keivan Gohari Moghadam Respiratory Disease Ward, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran. Mahbube Ebrahimpur Department of Internal Medicine, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran. 2019 03 14 2019 06 18 Introduction: Gaucher Disease is an autosomal recessive lysosomal storage disease. Pulmonary involvement in Gaucher Disease is rare and often seen in the severe form of the disease with the worst outcome. Case Presentation: A 30-year-old man and known case of Gaucher Disease presented to our clinic with history of progressive dyspnea since 8 months ago. Pulmonary function test showed restrictive pattern. Chest CT scan revealed diffuse bilateral interlobular septal thickening and small interstitial nodules with ground glass opacities in lower lobes. Conclusion: Patients with Gaucher Disease that present with progressive dyspnea may have a manifestation of interstitial or alveolar lung disease. https://crcp.tums.ac.ir/index.php/crcp/article/view/260 https://crcp.tums.ac.ir/index.php/crcp/article/download/260/335