Tehran University of Medical Sciences
Case Reports in Clinical Practice
2538-2683
4
4
2020
04
30
Repeated Sepsis in an 83-Year-Old Man With Cancer With Long-Lasting Invasive Treatments
122
124
Masoomeh
Imanipour
Assistant Professor, Department of Critical Care, Nursing and Midwifery Care Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Nasrin
Rasoulzadeh
Assistant Professor, Department of Medical-Surgical Nursing, School of Nursing and Midwifery,Tehran University of Medical Sciences, Tehran, Iran.
Amin
Hosseini
MSc. Candidate in Medical-Surgical Nursing, School of Nursing and Midwifery, Tehran University of Medical Sciences, Tehran, Iran.
2019
08
11
2019
08
11
Sepsis is a life-threatening condition that arises when the body's response to infection damages its own tissues and organs. Sepsis is caused by an inflammatory immune response triggered by an infection. Its risk factors include aging, weak immune system, major trauma, or burns. Treatment of sepsis is often based on fluid replacement and antibiotic therapy. In this study, an 83-year-old man is reported with two times of diagnosis of sepsis during three years. The first sepsis was due to an infection of the colostomy and the second one followed an infection at tracheostomy site. It seems that the disease and the underlying condition of the patient contribute to the occurrence of sepsis. The patient each time was discharged from the hospital after successful response to the treatment.
https://crcp.tums.ac.ir/index.php/crcp/article/view/295
https://crcp.tums.ac.ir/index.php/crcp/article/download/295/336
as being treated by sertraline 100 mg/daily plus quetiapine 25md per night for 15 months. She also presented peripheral type of Bell`s palsy while using this combination therapy. Neurological investigations also performed and all results were normal. She recovered after reduction of quetiapine dosage to 12.5 mg per night and prescription of acyclovir and dexamethasone by our neurologist colleague.
Discussion: Based on our search there is no reported correlation between psychiatric medications and Bell`s palsy. First explanation about our cases is an accidental correlation but also the short time correlation between initiation of treatment and presenting Bell’s palsy in first case and recovery of second one after reduction of quetiapine dosage are supporting the idea that the combination of sertraline and quetiapine may causes Bell’s palsy. Some articles have mentioned that antipsychotic drugs may have a weak antibiotic agent role and specially may demonstrate an inhibitory effect on neurotropic viruses, such as herpes simplex. Sertraline may also acts as an antibacterial agent. Reduction of protecting human microbiota may explain our observations.
Conclusion: Combination of sertraline and quetiapine may cause Bell`s palsy and clinicians should consider neurological adverse effects of this common combination.
https://crcp.tums.ac.ir/index.php/crcp/article/view/330
https://crcp.tums.ac.ir/index.php/crcp/article/download/330/356