Tehran University of Medical Sciences Case Reports in Clinical Practice 2538-2683 5 1 2020 07 12 23 26 Arghavan Fariborzifar Student Research Committee, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. Forouzan Elyasi Department of Psychiatry, Psychiatry and Behavioral Sciences Research Center, Sexual and Reproductive Health Research Center, Iranian National Center for Addiction Studies, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. Marziyeh Azizi Ph.D. Student of Reproductive Health, School of Nursing and Midwifery, Tehran University of Medical Sciences, Tehran, Iran. 2019 08 30 2019 12 14 Introduction: Antipsychotics (APs) can induce pathological blood clotting. Deep Vein Thrombosis (DVT) is a common type of Venous Thromboembolism (VTE) and a significant cause of morbidity and mortality worldwide. First or second generation APs have been specifically correlated with an increased risk of thromboembolism. Case presentation: We report a case of a bipolar female patient who developed DVT following an increase in her daily dose of APs (olanzapine and chlorpromazine). Conclusion: Physicians in other medical fields, including internal medicine and surgery, should be trained about the complication of DVT induced by APs. https://crcp.tums.ac.ir/index.php/crcp/article/view/299 https://crcp.tums.ac.ir/index.php/crcp/article/download/299/346