Tehran University of Medical Sciences Case Reports in Clinical Practice 2538-2683 5 1 2020 07 12 30 34 Mohammad Taghi Najafi Nephrology Research Center, Center of Excellence in Nephrology, Tehran University of Medical Sciences, Tehran, Iran. Pouya Mahdavi Sharif Department of Internal Medicine, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Azam Alamdari Nephrology Research Center, Center of Excellence in Nephrology, Tehran University of Medical Sciences, Tehran, Iran. Neda Naderi Nephrology Research Center, Center of Excellence in Nephrology, Tehran University of Medical Sciences, Tehran, Iran. 2019 11 01 2019 12 14 Gitelman syndrome is an inherited disorder of kidney function characterized by hypokalemia, hypomagnesemia, and hypocalciuria. Its first presentation during pregnancy might be a challenging diagnostic and management issue, as there is little data available in the medical literature. Here we report a 26-year-old pregnant woman who was diagnosed with Gitelman syndrome for the first time during her second trimester of pregnancy. Refractory hypokalemia in the 18th week of pregnancy was treated with eplerenone. The pregnancy outcome was favorable both for the mother and neonate. https://crcp.tums.ac.ir/index.php/crcp/article/view/310 https://crcp.tums.ac.ir/index.php/crcp/article/download/310/348