Tehran University of Medical Sciences Case Reports in Clinical Practice 2538-2683 5 3 2020 11 24 72 76 Siavash Abedi Department of Internal Medicine, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. Ali Sharifpour Department of Internal Medicine, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran, Masoud Aliyali Department of Internal Medicine, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. Fatemeh Niksolat Department of Internal Medicine, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran, Seyyed Abbas Hashemi Department of Internal Medicine, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. Amir Shamshirian Department of Medical Laboratory Sciences, Student Research Committee, School of Allied Medical Science, Mazandaran University of Medical Sciences, Sari, Iran AND Gastrointestinal Cancer Research Center, Mazandaran University of Medical Sciences, Sari, Iran. 2020 01 21 2020 04 02 Systemic Lupus Erythematosus (SLE) known as “lupus” is an autoimmune disease that mostly affects women. In this disorder, the body’s immune system attacks different tissues. Manifestations and symptoms vary among individuals from mild to severe. One of the most common manifestations of lupus is pleuritis with pleural effusion; however, its manifestation as the initial symptom of the disease is remarkably rare. Herein, we present a 17-year-old female with SLE, which was diagnosed with early pleural effusion regarding rheumatologic counseling subjected to treatment. https://crcp.tums.ac.ir/index.php/crcp/article/view/331 https://crcp.tums.ac.ir/index.php/crcp/article/download/331/358