Tehran University of Medical Sciences Case Reports in Clinical Practice 2538-2683 5 3 2020 11 24 86 88 Mona Talaschian Department of Internal Medicine, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Anahita Sadeghi Digestive Diseases Research Institute, Shariati Hospital ,Tehran University of Medical Sciences, Tehran, Iran. Sara Pakzad Department of Medical-Surgical Nursing, School Nursing & Midwifery, Tehran University of Medical Sciences, Tehran, Iran. 2020 02 17 2020 04 02 Carbamazepine(CBZ) is an effective first line treatment for trigeminal neuralgia and has an important place in the management of epilepsy and bipolar disorder. The potential for clinically important drug interactions exists because CBZ may induce the hepatic metabolism of other drugs or, conversely, other drugs may induce or inhibit the metabolism of CBZ.CBZ  is including  big group   of antiepileptic drugs that is widely used to prevent and control seizures. It has been associated with several cutaneous side effects, in  this case reported  a young woman who presented  with dyspnea, weight loss, pancytopenia, abdominal pain and oligomenorrhea and two weeks history of hyperpigmented lesions over her face, neck and two hands. She had history of seizures and did well on carbamazepine for 7 months ago, carbamazepine was withdrawn and she was treated with local emollients. The lesions were partially improved in 2 weeks. https://crcp.tums.ac.ir/index.php/crcp/article/view/341 https://crcp.tums.ac.ir/index.php/crcp/article/download/341/364