Tehran University of Medical Sciences Case Reports in Clinical Practice 2538-2683 5 4 2021 01 16 128 130 Narjes Zarei Jalalabadi Department of Internal Medicine, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran. Morteza Daraei Department of Internal Medicine, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran. Samaneh Parsa Department of Internal Medicine, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran. Neda Faraji Department of Internal Medicine, Baharlo Hospital, Tehran University of Medical Sciences, Tehran, Iran. 2020 05 24 2020 07 03 A 28-year-old woman with a history of transfusion-dependent thalassemia major who did not receive any iron-chelating agent presented with symptoms of iron overload with marked diffuse increased liver density. Eventually, the diagnosis of secondary hemochromatosis was done based on the aforementioned history, laboratory, and imaging findings. https://crcp.tums.ac.ir/index.php/crcp/article/view/358 https://crcp.tums.ac.ir/index.php/crcp/article/download/358/374