Tehran University of Medical Sciences Case Reports in Clinical Practice 2538-2683 6 2 2021 08 07 42 46 Elham Kazemi Jahromi Department of Pathology, Shahid Mohammadi Hospital, Hormozgan University of Medical Sciences, Bandar Abbas, Iran. Hakimeh Sajjadi Department of pathology, Shahid Mohammadi Hospital, Hormozgan University of Medical Sciences, Bandar Abbas, Iran 2020 06 19 2020 07 12 Primary gallbladder cancer is a rare malignancy and it is difficult to be diagnosed because there are no specific signs and symptoms at the initial stage. The most important risk factors include female gender, the age of more than 65 years, and having large gallstones. The authors present a rare and unusual case of adenocarcinoma of the gallbladder because the reported case is a male patient from Asia and had acalculous cholecystitis. https://crcp.tums.ac.ir/index.php/crcp/article/view/369