Tehran University of Medical Sciences Case Reports in Clinical Practice 2538-2683 6 3 2021 10 06 94 98 EN Niayesh Mohebbi Department of Clinical Pharmacy, Schoolof Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. Hamidreza Taghvaye-Masoumi Department of Clinical Pharmacy, Faculty of Pharmacy, Guilan University of Medical Sciences, Rasht, Iran. Malihe Khosravi-Khezri Department of Clinical Pharmacy, Hasheminejad Kidney Center, Iran University of Medical Sciences, Tehran, Iran. Mona Talaschian Department of Internal Medicine, Shariat Hospital, Tehran University of Medical Sciences, Tehran, Iran. 2020 07 14 2020 08 04 Sulfasalazine, a non-antibiotic sulfonamide, is associated with severe hypersensitivity reactions, including Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome. We report a case of sulfasalazine-induced DRESS syndrome that relapsed following the administration of visipaque® (iodixanol). Macular rashes, pruritus, and an acute exacerbation of dyspnea were immediately observed after the administration of contrast media. It seems that patients suffering from DRESS syndrome are sensitive to the administration of other new medications with a high possibility of hypersensitive reactions. It can be concluded that iodinated contrast media should be used cautiously in patients with DRESS syndrome. https://crcp.tums.ac.ir/index.php/crcp/article/view/380 https://crcp.tums.ac.ir/index.php/crcp/article/download/380/409