Tehran University of Medical Sciences Case Reports in Clinical Practice 2538-2683 6 4 2021 11 27 169 172 Maryam Vosoughian Department of Anesthesiology & Critical Care, Anesthesiology Research Center, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran Shideh Dabir Department of Anesthesiology & Critical Care, Tracheal Diseases Research Center, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Mastaneh Dahi Department of Anesthesiology & Critical Care, Anesthesiology Research Center, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Mohammadreza Moshari Department of Anesthesiology & Critical Care, Anesthesiology Research Center, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 2020 10 05 2021 04 26 In this report, we presented our experience in treating severe postpartum post-dural puncture headache with low-dose propofol. Short-term use of low-dose propofol provided rapid and complete relief of the headache without recurrence. https://crcp.tums.ac.ir/index.php/crcp/article/view/410