Tehran University of Medical Sciences Case Reports in Clinical Practice 2538-2683 6 5 2022 01 17 205 209 Vajihe Aghamollaii Posterior Cortical Atrophy (PCA) is a rare neuropsychiatric syndrome characterized by the dominancy of visuospatial impairments due to bilateral parieto-occipital divesting with the most common pathological changes presented in typical Alzheimer’s Disease (AD). We reported 3 cases with similar diagnoses and interesting manifestations in this study. Gradual onset and progression of visual deficits without underlying ophthalmologic disease accompanied by intact memory and fluent speech and also the presence of simultagnosia, optic ataxia, oculomotor apraxia, dyscalculia, finger agnosia, and environmental disorientation, and the absence of any history of related diseases; all of them strongly suggesting posterior cortical atrophy. Setareh Fathollahzadeh Noor Department of Psychiatry, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran. Reza Bidaki Research Center of Addictionand Behavioral Sciences, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.AND Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Elmira Agah School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. 2020 11 25 2021 04 12 Posterior Cortical Atrophy (PCA) is a rare neuropsychiatric syndrome characterized by the dominancy of visuospatial impairments due to bilateral parieto-occipital divesting with the most common pathological changes presented in typical Alzheimer’s Disease (AD). We reported 3 cases with similar diagnoses and interesting manifestations in this study. Gradual onset and progression of visual deficits without underlying ophthalmologic disease accompanied by intact memory and fluent speech and also the presence of simultagnosia, optic ataxia, oculomotor apraxia, dyscalculia, finger agnosia, and environmental disorientation, and the absence of any history of related diseases; all of them strongly suggesting posterior cortical atrophy. https://crcp.tums.ac.ir/index.php/crcp/article/view/424