Tehran University of Medical Sciences Case Reports in Clinical Practice 2538-2683 6 S1 2022 07 06 265 268 Hajrah Ahmed General Surgery Surgical Unit II, Abbasi Shaheed Hospital, Karachi, Pakistan. Ayesha Siddiqui House Officer, Surgical Unit II, Abbasi Shaheed Hospital, Karachi, Pakistan. Kanwal Irshad General Surgery Surgical Unit II, Abbasi Shaheed Hospital, Karachi, Pakistan. Muhammad Jamaluddin Karachi Medical & Dental, Karachi, Pakistan. 2020 12 07 2021 12 01 Squamous Cell Carcinoma (SCC) of the scrotum has a considerably low incidence and is directly linked to exposure to occupational carcinogens. We present a case of an 80-year- old male patient with a long history of multiple painless swellings in the scrotum. The investigations showed the lesions confined to the skin with the involvement of some draining lymph nodes, and the histopathology came to be Scrotal Squamous Cell Carcinoma. Due to lymph node involvement, the lesions were of TNM (Tumor size, Nodal involvement, Distant Metastasis) staging 4 and Lowe’s stage B. Wide surgical excision combined with radiotherapy was done. There is a lack of research about the disease worldwide and in Pakistan, which warrants further interest in optimizing diagnostics and therapeutics modalities and assessing geographical variation. https://crcp.tums.ac.ir/index.php/crcp/article/view/429