Tehran University of Medical Sciences Case Reports in Clinical Practice 2538-2683 6 6 2022 04 11 223 226 Mahavishnu Sahadevan Kuala Lumpur General Hospital Kushanthini Sivaloganathan Department of Emergency Medicine, Seremban General Hospital, Seremban, Malaysia. Tung Yu Feng Department of Internal Medicine, Kuala Lumpur General Hospital, Kuala Lumpur, Malaysia. 2020 12 08 2021 04 12 Cerebral Autosomal Dominant Arteriopathy with Sub-Cortical Infarcts and Leukoencephalopathy (CADASIL) is a rare autosomal genetic disorder that affects the brain’s small vessels. It is recognized among the leading causes of stroke in the young. This is a case report of a 35-year-old female with underlying migraine with auras who presented with recurrent cryptogenic strokes. She presented no vascular risk factors or any family history of neurological disease. An investigation into her presentation leads us to a diagnosis of CADASIL following typical subcortical and deep white matter changes seen on her Magnetic Resonance Imaging (MRI). https://crcp.tums.ac.ir/index.php/crcp/article/view/430