Tehran University of Medical Sciences Case Reports in Clinical Practice 2538-2683 6 S1 2022 07 06 269 270 Mohsen Esfandbod Department of Hematology and Oncology, Imam Khomeini Hospital Complex, Tehran University Medical Science, Tehran, Iran. Bahareh Shateri Amiri Department of Internal Medicine, Imam Khomeini Hospital Complex, Tehran University Medical Science, Tehran, Iran. 2020 12 25 2021 01 18 35-year-old woman presented to the dermatology clinic complaining of lax skin and atrophic and pendulous plaques in axillary, inguinal folds, and deltoid region. Initially, lesions were indurated plaques, which slowly became wrinkled.Histopathologic evaluation showed Pandermal and subcutaneous infiltrate of atypical lymphocytes admixed with evenly distributed epithelioid and multinucleated giant cells, many of which contain numerous nuclei. Histopathology and clinical findings were consistent with the diagnosis of Granulomatous slack skin. https://crcp.tums.ac.ir/index.php/crcp/article/view/444