Tehran University of Medical Sciences Case Reports in Clinical Practice 2538-2683 6 6 2023 01 21 235 238 Alpha Madu Department of Medicine, Russells Hall Hospital, Dudley Group NHS Foundation Trust, Dudley, United Kingdom. Mohammed Moqsith Department of Medicine, Kettering General Hospital, Kettering, United Kingdom Ajmal Raoof Department of Medicine, Kettering General Hospital, Kettering, United Kingdom. 2021 01 04 2021 05 10 An elderly woman aged 66 presented to a general hospital with left-sided facial paresis, bilateral lower limb weakness, and back pain. After undergoing clinical assessments and investigations, she was diagnosed and treated as a case of acute stroke. Two weeks later, she was repatriated to our hospital for neuro-rehabilitation. Unconvinced, we revisited her clinical history and, after a thorough physical examination, made a clinical diagnosis of Guillain- Barre Syndrome (GBS), i.e., confirmed by electrophysiological studies. She was treated with intravenous immunoglobulin and made a complete recovery 6 weeks later. This case highlights an infrequent presentation of GBS as a stroke-mimic. It re-emphasizes the need to maintain a high index of clinical suspicion for similar expressions, especially in busy acute medical units. Such cases are easily missed if basic clinical skills, such as good history- taking and thorough physical examination, are glossed over. Despite time constraints, these skills are indispensable in clinical practice. https://crcp.tums.ac.ir/index.php/crcp/article/view/449