Tehran University of Medical Sciences Case Reports in Clinical Practice 2538-2683 6 6 2022 04 12 239 241 Murat Selçuk Department of Cardiology, Sultan II. Abdülhamid Han Training and Research Hospital, Health Sciences University, Istanbul, Turkey. Tufan Cinar Department of Cardiology, Sultan II. Abdülhamid Han Training and Research Hospital, Health Sciences University, Istanbul, Turkey. Vedat Çiçek Department of Cardiology, Sultan II. Abdülhamid Han Training and Research Hospital, Health Sciences University, Istanbul, Turkey. Şahhan Kılıç Department of Cardiology, Sultan II. Abdülhamid Han Training and Research Hospital, Health Sciences University, Istanbul, Turkey. Emre Yalçınkaya Department of Cardiology, Sultan II. Abdülhamid Han Training and Research Hospital, Health Sciences University, Istanbul, Turkey. Ahmet Orhan Department of Cardiology, Sultan II. Abdülhamid Han Training and Research Hospital, Health Sciences University, Istanbul, Turkey. 2021 01 07 2021 05 10 Coronavirus Disease 2019 (COVID-19) is an ongoing pandemic caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Patients with infective endocarditis (IE) and COVID-19 can present similar signs and symptoms; thus, it may be difficult for clinicians to diagnose such infections. This report presented a patient diagnosed with IE and co-infected with COVID-19. This case highlights that every physician should consider COVID-19 infection when evaluating patients with IE. https://crcp.tums.ac.ir/index.php/crcp/article/view/451