Tehran University of Medical Sciences Case Reports in Clinical Practice 2538-2683 7 5 2023 02 12 221 226 Priscilla Duran Luciano Department of Medicine, Albert Einstein College of Medicine, New York, USA. 2021 11 04 2022 01 16 Non-neoformans Cryptococcus species were formerly considered to be saprophytes and nonpathogenic to humans [1-2]. However, the incidence of Cryptococcus laurentii infections in immunocompromised and immunocompetent patients has been gradually increasing over the last decades [1-2]. During the COVID-19 pandemic, multiple cases of opportunistic bacterial and fungal infections have been reported in patients after a severe SARS-CoV-2 infection. The author reports the first case of opportunistic pulmonary cryptococcosis caused by Cryptococcus laurentii in a severely ill COVID-19 patient who received treatment with Tocilizumab and dexamethasone. This case contributes to the expanding knowledge of emergent secondary infectious complications including opportunistic pathogens after a SARS-COV-2 infection. https://crcp.tums.ac.ir/index.php/crcp/article/view/617