Tehran University of Medical Sciences Case Reports in Clinical Practice 2538-2683 7 6 2023 03 12 275 279 Shaghayegh Ashraf Talesh Department of Infectious Diseases, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran. Sara Zare School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Azar Hadadi Department of Infectious Diseases, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran. 2022 02 11 2022 05 08 Neurological symptoms like headache have been reported in patients infected with tuberculosis (TB) and COVID-19 infection [1]. A high index of suspicions is necessary for diagnosing of COVID-19 and neurologic tuberculous coinfection, particularly in the communities at high risk for TB or in an endemic region. Herein, we report a case of a 60-year-old man diagnosed with acute COVID-19 and tuberculous meningitis coinfection, to emphasize challenges about this coinfection, because underlying lung diseases like latent TB will affect the clinical categorization (for severity) of COVID-19, and then active TB disease may severe illness. https://crcp.tums.ac.ir/index.php/crcp/article/view/658