Tehran University of Medical Sciences Case Reports in Clinical Practice 2538-2683 7 5 2023 02 19 253 256 Sepideh Paybast Multiple Sclerosis Research Center, Neuroscience Institute,Tehran University of Medical Sciences, Tehran, Iran. Abdorreza Naser Moghadasi Multiple Sclerosis Research Center, Neuroscience Institute,Tehran University of Medical Sciences, Tehran, Iran. 2022 04 20 2022 06 01 There are limited reports of oculomotor nerve palsy following vaccination. Herein, we aimed to report a case of acute oculomotor nerve palsy following the first dose of the Sinopharm vaccine. A 17-year-old woman presented with a history of acute painful diplopia and right ptosis within a week after receiving the first dosage of the Sinopharm vaccine. The neurological examination was compatible with acute right third nerve palsy sparing pupils. All the para-clinical tests were unremarkable. With a diagnosis of possible oculomotor nerve palsy as an adverse event of the COVID-19 vaccine, she was treated with steroids leading to a significant recovery. We reported the first case of acute oculomotor nerve palsy associated with the Sinopharm vaccine. However, our findings dose not conclude a causal association between oculomotor nerve palsy and COVID-19 vaccination. https://crcp.tums.ac.ir/index.php/crcp/article/view/680