Tehran University of Medical Sciences Case Reports in Clinical Practice 2538-2683 1 3 2017 01 09 85 88 EN Simin-Dokht Shoaei Department of Infectious Diseases, Clinical Research and Development Center, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran Mohamad Farahbakhsh Infectious Diseases and Tropical Medicine Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Mehrdad Haghighi Department of Infectious Diseases, Clinical Research and Development Center, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran Fahime Hadavand Department of Infectious Diseases, Clinical Research and Development Center, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran 2016 06 24 2016 08 03 Neurologic involvement occurs in approximately 10% cases of brucellosis and is a serious complication. It manifests with unique and some rare manifestations. We present the first patient with seizures in Brucella meningitis without encephalitis, space-occupying lesion, or vascular involvement. The patient is a 23-year-old man with complaint of seizure. He had generalized weakness for 2 weeks before. In 1st day of admission, he had the second convulsion. Cerebrospinal fluid (CSF) on admission showed lymphocytic pleocytosis and high protein. Brain magnetic resonance imaging and computed tomography scan were normal. Further evaluations resulted a positive Wright, Coombs’ Wright, and 2- mercaptoethanol (2ME) tests. Specific regimen with rifampin, doxycycline, and ceftriaxone in the 1st month then the first two with trimethoprimsulfamethoxazole (TMP-SMX) for 5 months administered. 6 months after completion of treatment in follow-up he has no seizure, systemic or localized symptoms. https://crcp.tums.ac.ir/index.php/crcp/article/view/70 https://crcp.tums.ac.ir/index.php/crcp/article/download/70/43