Tehran University of Medical Sciences Case Reports in Clinical Practice 2538-2683 7 6 2023 03 12 298 300 Azar Danesh Shahraki Department of Obstetrics and Gynecology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. Azam Zafarbakhs Department of Obstetrics and Gynecology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. Amirreza Farhadian Dehkordi Department of General Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. Taherh Khalili Brojeni Department of Obstetrics and Gynecology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. Fedyeh Haghollahi Vali-E-Asr Reproductive Health Research Center, Family Health Research Institute, Tehran University of Medical Sciences,Tehran, Iran. 2022 07 09 2022 10 03 Redo syndrome or acute hematometra is a rare complication after abortion or cesarean section.A-32- year-old woman with previous cesarean section, term pregnancy, and labor pain referred to hospital.She delivered a healthy baby with a good Apgar score and discharge 2 days later without complications after a cesarean section. She came back to the hospital with the severe abdominal pain, weakness, without abnormal bleeding, at 6 days postpartum. Abdominopelvic sonography showed a large hematometra in the uterus. She took misoprostol 200 μg intra vaginal and 200μg sublingual, plus serum oxytocin and cefazolin. After about 1.5 hours, she passed a large hematoma, her pain gradually relieved, and she was discharged three days later. This report show that misoprostol is useful in the management of acute hematometra. https://crcp.tums.ac.ir/index.php/crcp/article/view/711