Tehran University of Medical Sciences Case Reports in Clinical Practice 2538-2683 8 1 2023 07 22 46 49 Seyed Mohsen Rafizadeh Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran. Mehdi Aminizade Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran. Fahime Asadi Amoli Farabi eye hospitalEye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran. Mahtab Rabbani Anari Department of Otorhinolaryngology - Head & Neck Surgery, Amir Alam Hospital, Tehran University of Medical Sciences, Tehran, Iran. Mahmoud khodabandeh Department of Infectious Diseases, Pediatric’s Center of Excellence, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran. abbas mohammadi Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran. 2022 11 10 2023 04 26 Rhino-orbital mucormycosis in an immunocompetent pediatric patient can present as an orbital mass. We report a 9-year-old male that presented with periorbital swelling and limitation of left eye movement from one month ago. The patient was treated at another center with a diagnosis of mucormycosis but was referred due to worsening symptoms. Orbital and paranasal sinus CT scan revealed opacities in the left paranasal sinus and soft tissue density in the medial and inferior orbital wall. The patient underwent orbitotomy and mass debulking surgery on suspicion of a possible neoplastic mass. Pathologic evaluations revealed mucormycosis. After receiving intravenous liposomal amphotericin-B that was followed by oral posaconazole syrup for two months and sinus debridement, the symptoms regressed. In immunocompromised pediatric patients, mucormycosis should be considered in the differential diagnosis of an orbital mass. https://crcp.tums.ac.ir/index.php/crcp/article/view/754