Tehran University of Medical Sciences Case Reports in Clinical Practice 2538-2683 9 2 2024 11 06 48 51 EN Azam Zafarbakhsh Isfahan University of Medical Sciences, Isfahan, Iran Mohadese Poorpouneh Department of Internal Medicine, School of Medicine Isfahan University of Medical Sciences, Iran Samira Rafiee Department of Internal Medicine, School of Medicine Isfahan University of Medical Sciences, Iran 2023 08 26 2024 10 28 Glanzmann’s thrombasthenia (GT) is a rare genetic platelet disorder that leads to bleeding problems in affected individuals. We present a 28-year-old woman with GT who experienced a rare symptom of painless gross hematuria in the last month of pregnancy. To provide the best care, an interdisciplinary approach was followed by a team of obstetricians and gynecologists, hematologists, neonatologists, and anesthesiologists. The IUGR fetus was delivered by cesarean section and had mild acidosis and thrombocytopenia at birth. Both the baby and the mother were carefully cared for and treated. Hematuria also improved spontaneously within two weeks after delivery. Gross hematuria during pregnancy rarely occurs due to the pressure of the presenting part of the fetus on the mother’s bladder (due to engagement). Aggravation of any clinical symptoms in pregnant women with GT should alert maternal and fetal health care providers to make individualized decisions. https://crcp.tums.ac.ir/index.php/crcp/article/view/866 https://crcp.tums.ac.ir/index.php/crcp/article/download/866/653