Tehran University of Medical Sciences Case Reports in Clinical Practice 2538-2683 9 5 2025 04 26 192 195 EN Homayoun Nikkhah Ophthalmic Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran. AND Department of Ophthalmology, Torfeh Eye Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.. Kiana Hassanpour Ophthalmic Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Hamid Ahmadieh Ophthalmic Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Sadid Hooshmandi Ophthalmic Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Mohamad javad Babaki Ophthalmic Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 2024 06 06 2025 01 13 Endogenous endophthalmitis is caused by the hematogenous dissemination of infectious organisms, resulting in intraocular infection. This entity is uncommon and accounts for 5–15% of all forms of endophthalmitis. Patients with compromised immune systems are most at risk for endogenous endophthalmitis. An immunocompetent 20-year-old man, following a recent hospitalization and ventilator-associated pneumonia (VAP), presented with blurred vision in the left eye. Fundoscopy revealed dense white-toyellow, pus-like subfoveal material originating from the choroid, breaking through the retina, and dispersing into the vitreous. According to polymerase chain reaction (PCR) findings, the infection had a bacterial origin and caused irreversible damage to the macula. https://crcp.tums.ac.ir/index.php/crcp/article/view/959 https://crcp.tums.ac.ir/index.php/crcp/article/download/959/683