Tehran University of Medical Sciences Case Reports in Clinical Practice 2538-2683 9 1 2024 10 22 39 41 Nariman Khan Department of Diagnostic Radiology University of Texas Health Science Center San Antonio San Antonio, Texas, USA Isadora Linford Department of Diagnostic Radiology University of Texas Health Science Center San Antonio San Antonio, Texas, USA Sara Romero Department of Diagnostic Radiology University of Texas Health Science Center San Antonio San Antonio, Texas, USA 2024 06 09 2024 07 06 Breast cancer is highly prevalent amongs t older women but much less common in younger women, especially those under the age of 20 . Here we present a case of an 18-year-old woman with Neurofibromatosis 1 diagnosed with breast cancer. Review of literature demons trates a five-fold increased risk of developing breast cancer before age 50 with a mutation in this tumor suppressor gene. Incorporation of earlier screening recommenda tions for at-risk younger women is warranted in more guide lines. https://crcp.tums.ac.ir/index.php/crcp/article/view/962 https://crcp.tums.ac.ir/index.php/crcp/article/download/962/632