Tehran University of Medical Sciences Case Reports in Clinical Practice 2538-2683 9 1 2024 10 22 42 44 Isadora Linford Department of Diagnostic Radiology University of Texas Health Science Center San Antonio San Antonio, Texas, USA Nariman Khan Department of Diagnostic Radiology University of Texas Health Science Center San Antonio San Antonio, Texas, USA Sara Romero Department of Diagnostic Radiology University of Texas Health Science Center San Antonio San Antonio, Texas, USA 2024 06 09 2024 06 18 Epidermal inclusion cysts (EIC) are common cutaneous cysts that can occur nearly anywhere in the body with common locations being the face, scalp, neck, back, and scrotum. Only a few cases of EIC to the breast have been reported in literature to date, with most occurring after trauma to the breast. Here we present the case of a 35-year-old woman that presented with a nontraumatic nipple lesion that was later biopsy proven to be an EIC. Although not a primary consideration, EIC should be on the differential for skin lesions of the nipple. https://crcp.tums.ac.ir/index.php/crcp/article/view/963 https://crcp.tums.ac.ir/index.php/crcp/article/download/963/633