Tehran University of Medical Sciences Case Reports in Clinical Practice 2538-2683 9 2 2024 11 06 70 73 Zahra Sanayepasand Otorhinolaryngology Research Center, Tehran University of Medical Sciences, Tehran, Iran. Shirin Irani Otorhinolaryngology Research Center, Tehran University of Medical Sciences, Tehran, Iran. Mohammadreza Firouzifar Otorhinolaryngology Research Center, Tehran University of Medical Sciences, Tehran, Iran. Seyede Misha Seyednia Anesthesiology and Intensive Care, Amir-Alam Hospital, Tehran University of Medical Sciences, Tehran, Iran. Farrokh Heidari Otorhinolaryngology Research Center, Tehran University of Medical Sciences, Tehran, Iran. 2024 09 10 2024 10 01 Metastasis to the skull base is a rare but serious complication of various malignancies. This case report  discusses a 50-year-old woman with a history of advanced endometrialadenocarcinoma who presented with progressive headache, left-eye blindness, and ptosis. Imaging revealed a mass along the left optic nerve, raising suspicions of mucormycosis, but biopsy confirmed metastatic endometrial adenocarcinoma. Despite undergoing skull base radiotherapy, the patient’s vision did not improve. This case underscores the importance of considering metastatic endometrial adenocarcinoma in differential diagnoses for skull base lesions, particularly when other conditions are ruled out. Accurate diagnosis requires careful integration of clinical, radiological, and histopathological data. https://crcp.tums.ac.ir/index.php/crcp/article/view/985 https://crcp.tums.ac.ir/index.php/crcp/article/download/985/659