Tehran University of Medical Sciences Case Reports in Clinical Practice 2538-2683 9 3 2024 12 08 119 124 Victor Olaiya Department of Internal Medicine, Izhevsk State Medical University, Izhevsk, Russia. Vincentia Agyekum Department of Internal Medicine, Izhevsk State Medical University, Izhevsk, Russia. Adefunke Omotoso Department of Internal Medicine, School of Medicine & Dentistry, University of Central Lancashire, Fylde Rd, Preston PR1 2HE. 2024 10 15 2024 10 28 Superior vena cava syndrome (SVCS) is a clinical condition caused by the obstruction of venous return through the superior vena cava (SVC). This report presents a 71-year-old male diagnosed with central lung cancer and chronic obstructive pulmonary disease (COPD) complicated by SVCS. The report details his clinical presentation, diagnostic workup, and management, including chemotherapy and symptomatic treatment. SVCS can significantly affect patient outcomes, especially in cases of malignancy, and requires timely intervention. https://crcp.tums.ac.ir/index.php/crcp/article/view/992 https://crcp.tums.ac.ir/index.php/crcp/article/download/992/669