Tehran University of Medical Sciences Case Reports in Clinical Practice 2538-2683 9 3 2024 12 08 133 136 Ali Goudarzi Radiology Department, Shiraz University of Medical Sciences, Shiraz, Iran. AND Student Research Commitee, Shiraz University of Medical Sciences, Shiraz, Iran. Leila Ostovar Diagnostic Radiologist, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. 2024 11 01 2024 11 04 Pulmonary spindle cell carcinoma (PSCC) is a rare and highly aggressive form of nonsmall cell lung cancer with sarcomatoid differentiation. It poses significant diagnostic challenges due to its histological resemblance to other malignancies, including inflammatory myofibroblastic tumors. This case report details the clinical presentation, histopathological findings, and treatment of a patient with PSCC, to further elucidate the clinical features, diagnosis, and management of this rare tumor. https://crcp.tums.ac.ir/index.php/crcp/article/view/996 https://crcp.tums.ac.ir/index.php/crcp/article/download/996/671