Bilateral Large Squamous Cell Carcinoma on Both Groins with Metastasis to the Liver: A Case Report

  • Safoura Shakoei Assistant Professor, Department of Dermatology, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran.
  • Maryam Nasimi Assistant Professor, Department of Dermatology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran.
  • Alireza Ghanadan Associate Professor, Department of Dermopathology, Razi Hospital AND Department of Pathology, Cancer Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.
  • Sirous Jafari Associate Professor, Department of Infectious Disease, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.
  • Arghavan Azizpour Assistant Professor, Department of Dermatology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Keywords: Squamous cell carcinoma, Groin, Pathology, Metastasis

Abstract

Cutaneous squamous cell carcinoma (cSCC), which is the second most common malignancy in humans, commonly occurs on sun-exposed skin such as face. Incidence rate of squamous cell carcinoma is found to be higher in old men. Metastatic rate of cutaneous squamous cell carcinoma is approximately 4-5%, and it is higher in men, especially those over the age of 75 years. Risk factors that increase the rate of metastatic SCC include immunosuppression like human immunodeficiency virus (HIV), solid organ transplantation, tumor thickness (> 2 mm), lesion diameter (> than 2 cm), poor differentiation, and perineural invasion. To our knowledge, our case is the first report of squamous cell carcinoma with large size with bilateral lesion extending from the groin to intergluteal region.

Author Biography

Safoura Shakoei, Assistant Professor, Department of Dermatology, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Dermatology

References

Burton KA, Ashack KA, Khachemoune A. Cutaneous squamous cell carcinoma: A review of high-risk and metastatic disease. Am J Clin Dermatol 2016; 17(5): 491-508.

Dacosta Byfield S, Chen D, Yim YM, Reyes C. Age distribution of patients with advanced nonmelanoma skin cancer in the United States. Arch Dermatol Res 2013; 305(9): 845-50.

Toll A, Margalef P, Masferrer E, FerrandizPulido C, Gimeno J, Pujol RM, et al. Active nuclear IKK correlates with metastatic risk in cutaneous squamous cell carcinoma. Arch Dermatol Res 2015; 307(8): 721-9.

Brantsch KD, Meisner C, Schonfisch B, Trilling B, Wehner-Caroli J, Rocken M, et al. Analysis of risk factors determining prognosis of cutaneous squamous-cell carcinoma: A prospective study. Lancet Oncol 2008; 9(8): 713-20.

Askari M, Kakar S, Moran SL. Squamous cell carcinoma of the hand: A 20-year review. J Hand Surg Am 2013; 38(11): 2124-33.

Cherpelis BS, Marcusen C, Lang PG. Prognostic factors for metastasis in squamous cell carcinoma of the skin. Dermatol Surg 2002; 28(3): 268-73.

Fino P, Spagnoli AM, Ruggieri M, Marcasciano M, Scuderi N. Bilateral hand squamous-cells carcinoma in patient affected with non-Hodgkin lymphoma. Case report and literature review. G Chir 2015; 36(4): 172-82.

Wolfe SG, Lai SY, Bigelow DC. Bilateral squamous cell carcinoma of the external auditory canals. Laryngoscope 2002; 112(6): 1003-5.

Hodgson N, Whipple K, Lin JH, Brumund KT, Kikkawa DO, Korn BS. Bilateral squamous cell carcinoma of the lacrimal sac. Ophthal Plast Reconstr Surg 2013; 29(6): e149-e151.

Trodello C, Pepper JP, Wong M, Wysong A. Cisplatin and cetuximab treatment for metastatic cutaneous squamous cell carcinoma: A systematic review. Dermatol Surg 2017; 43(1): 40-9.

Published
2018-05-14
How to Cite
1.
Shakoei S, Nasimi M, Ghanadan A, Jafari S, Azizpour A. Bilateral Large Squamous Cell Carcinoma on Both Groins with Metastasis to the Liver: A Case Report. CRCP. 2(4):116-9.
Section
Case Report(s)