Limb Cutis Aplasia With Brain Thrombosis

  • Razieh Sangsari Department of Neonatology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  • Saeid JedaryAttary
  • Maliheh Kadivar
Keywords: Skin;, Thrombosis;, Brain ischemia


Cutis aplasia is a rare, benign, congenital, and localized skin defect disorder with multiple underlying causes. Vascular events are one of the underlying causes. However, they are not a common cause. Small cutis aplasia without bony defect gradually heals without any complication. Rare complications are seen in scalp aplasia with bony defect like hemorrhage, meningitis and thrombosis. We reported a neonate with limb skin aplasia of 4×3 cm size and normal other physical signs and symptoms. Gradually he developed overriding of skull sutures near his discharge time. We found a similar picture of the brain ischemia in imaging on the 24th day of his birth. This case and the similar cases may sugges an association between the vascular events and the cause of the disease. Thus, it is important to consider thrombosis and other vascular events in every patient with cutis aplasia even in a neonate with normal examination in the frs day. We recommend that physicians should not judge that the disease always has a good prognosis and follow up the patients’ condition anyway.

Author Biography

Razieh Sangsari, Department of Neonatology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Department of Neonatology, School of Medicine, Tehran University of Medical Sciences, Tehran, IranAssistant professor


- Burkhead A, Poindexter G, Morrell DS .A case of extensive Aplasia Cutis Congenita with underlying skull defect and central nervous system malformation: discussion of large skin defects, complications, treatment and outcome. J. Perinatol. 2009; 29(8):582-4. doi: 10.1038/jp.2008.250.PubMed PMID: 19638992

- Dahmardehei MA. Rare Case of Aplasia Cutis Congenita. Acta Medica Iranica. 2013; 51(5): 341-4. PubMed PMID: 23737321

- Abulezz TA, Shalkamy MA. Aplasia cutis congenita: Two cases of non-scalp lesions. Indian J Plast Surg. 2009 Jul-Dec; 42(2): 261–4. doi: 10.4103/0970-0358.59297.PubMed PMID: 20368873; PubMed Central PMCID: PMC2845380

- Brzezinski P, Pinteala T, Chiriac AE, Foia L. Chiriac A.Aplasia cutis congenita of the scalp- what are the steps to be followed? An Bras Dermatol. 2015;90(1):100-3. doi: 10.1590/abd1806-4841.20153078 .PubMed PMID: 25672305 ; PubMed Central PMCID :PMC4323704

- Bharti G, Groves L, Lisa RD., Sanger C, Aplasia Cutis Congenita. J Craniofac Surg 2011;22: 159-65. doi: 10.1097/SCS.0b013e3181f73937. PubMed PMID: 21187755.

- O’Neill J.K., Carter M., Warr R.P. Aplasia cutis congenita. A case of scalp defect repair using two opposing bipedicled local flaps, Journal of Plastic, Reconstructive & Aesthetic Surgery .2010; 63:242-4 doi: 10.1016/j.bjps.2009.06.005. PubMed PMID: 19577972

- Kantor J ,Yan AC, Hivnor CM, Extensive Aplasia Cutis Congenita and the Risk of Sagittal Sinus Thrombosis. Arch Dermatol. 2005;141(5):554-556. doi: 10.1001/archderm.14

How to Cite
Sangsari R, JedaryAttary S, Kadivar M. Limb Cutis Aplasia With Brain Thrombosis. CRCP. 3(3):83-6.
Case Report(s)