Rhino-Orbito-Cerebral Mucormycosis Following Tooth Extraction in a Diabetic Patient: A Case Report
Abstract
Mucormycosis is a rare, aggressive, and often fatal fungal infection that primarily affects immunosuppressed and diabetic patients, causing soft-tissue lesions. Early detection and prompt management are crucial. We present a case of mucormycosis following dental extraction in a patient with diabetes. A 48-year-old diabetic Iranian Baluch woman with multiple dental caries developed left eye exophthalmia and headache one week after an Afghan unlicensed dentist in Iran extracted four teeth from her left maxilla to alleviate pain and inflammation in her maxillary premolars and molars. Diagnostic tests confirmed that mucormycosis had spread from the extraction site to the surrounding soft tissue, sinuses, left eye, and brain. Diabetes significantly
increases the risk of mucormycosis infections. In patients with tooth caries and infections, mucormycosis should be considered as a potential diagnosis. Timely diagnosis and treatment are crucial prior to dental procedures to prevent spread to the sinuses and brain.
review. Ann Med. 2024 Dec;56(1):2396570. https://doi.org/10.1080/07853890.2024.2396570
[2] Reid G, Lynch JP 3rd, Fishbein MC, Clark NM. Mucormycosis. Semin Respir Crit Care Med. 2020 Feb;41(1):99-114. https://doi.org/10.1055/s-0039-3401992
[3] Rajashri R, Muthusekhar M. R, Kumar SP. Mucormycosis Following Tooth Extraction in a Diabetic Patient: A Case
Report. Cureus. 2020;12(8):e9757. https://doi.org/10.7759/cureus.9757
[4] Mora-MartÃnez A, Murcia L, RodrÃguez-Lozano FJ. Oral Manifestations of Mucormycosis: A Systematic Review. J
Fungi (Basel). 2023 Sep 16;9(9):935. https://doi.org/10.3390/jof9090935
[5] Motaleb HY, Mohamed MS, Mobarak FA. A Fatal Outcome of Rhino-orbito-cerebral Mucormycosis Following Tooth
Extraction: A Case Report. J Int Oral Health. 2015;7(Suppl 1):68-71.
[6] Siroos B, Sharify Bahram Z, Ghaemi O, Zia Ziabari S, M. HY. A case of progressive rhino-orbital mucormycosis involvingRastegari Najafabadi H et al. Rhino-Orbito-Cerebral Mucormycosis Following Tooth Extraction. CRCP. 2025; 10(6):253-259 259 November/December 2025, Volume 10, Issue 6 the brain via direct extension, retrograde perineural
spreading and middle cerebral artery vasculopathy. Arch Clin Infect Dis. 2014;9(3):e17580. https://doi.org/10.5812/
archcid.17580
[7] Bhattacharyya A, Sarma P, Sharma DJ, Das KK, Kaur H, Prajapat M, et al. Rhino-orbital-cerebral-mucormycosis in COVID-19: A systematic review. Indian J Pharmacol. 2021;53(4):317-27. https://doi.org/10.4103/ijp.ijp_419_21
[8] Alqarihi A, Kontoyiannis DP, Ibrahim AS. Mucormycosis in 2023: an update on pathogenesis and management. Front
Cell Infect Microbiol. 2023 Sep 21;13:1254919. https://doi.org/10.3389/fcimb.2023.1254919
| Files | ||
| Issue | Vol 10 No 6 (2025): November- December | |
| Section | Case Report(s) | |
| Keywords | ||
| Mucormycosis Dental extraction Diabetes mellitus Fungal infection Cerebrovascular accidents Sinusitis | ||
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