Amyloidosis With Periorbital Rash
Abstract
We presented a middle-aged woman with nonspecifc signs and symptoms, including dyspnea, lower limb edema, and elevated jugular venous pressure. Among these, the skin changes including nail changes, macroglossia and periorbital rash were the mos important clues to suspect primary amyloidosis. Paraclinical sudies were anemia, proteinuria and resricted cardiomyopathy. Abdomi nal fat pad biopsy is usually the frs sep to confrm the amyloidosis. However, despite the negative hisologic result of fat-pad biopsy, we performed duodenal biopsy that confrmed amyloidosis. This case report demonsrates the important value of duodenal tissue in order to conform the diagnosis of amyloidosis.
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[10] Gameren IIV, Hazenberg BP, Bijzet J, Rijswijk MHV. Diagnostic accuracy of subcutaneous abdominal fat tissue aspiration for detecting systemic amyloidosis and its utility in clinical practice. Arthritis & Rheumatology. 2006; 54(6):2015-21. [DOI:10.1002/art.21902] [PMID]
[11] Tada S, Iwashita A, Matsui T, Fuchigami T, Yamamoto T, Yao T, et al. Endoscopic and biopsy fndings of the upper digestive tract in patients with amyloidosis. Gastrointestinal Endoscopy. 1990; 36(1):10-4. [DOI:10.1016/S0016- 5107(90)70913-3]
[12] Swan N, Skinner M, O’hara CJ. Bone marrow core biopsy specimens in AL (primary) amyloidosis: A morphologic and immunohistochemical study of 100 cases. American Journal of Clinical Pathology. 2003; 120(4):610-6. [DOI:10.1309/ PFUGHBX0TY20E08U] [PMID]
[2] Rajkumar SV, Dimopoulos MA, Palumbo A, Blade J, Merlini G, Mateos MV, et al. International myeloma working group updated criteria for the diagnosis of multiple myeloma. The lancet Oncology. 2014; 15(12):e538-e48. [DOI:10.1016/S1470- 2045(14)70442-5]
[3] Falk RH, Comenzo RL, Skinner M. The systemic amyloidoses. New England Journal of Medicine. 1997; 337(13):898 909. [DOI:10.1056/NEJM199709253371306] [PMID]
[4] Hazenberg BP. Amyloidosis: A clinical overview. Rheumatic Diseases Clinics of North America. 2013; 39(2):323-45. [DOI:10.1016/j.rdc.2013.02.012] [PMID]
[5] Benson M, Witt T, Bonnin J, Matthews B, Abonour R. Light chain (AL) amyloidosis in the Central Nervous System (CNS). Amyloid. 2011; 18(supp1):112-3. [DOI: 10.3109/13506129.201 1.574354041] [PMID]
[6] Huang X, Wang Q, Jiang S, Chen W, Zeng C, Liu Z. The clinical features and outcomes of systemic AL amyloidosis: A cohort of 231 Chinese patients. Clinical Kidney Journal. 2014; 8(1):120-6. [DOI:10.1093/ckj/sfu117] [PMID] [PMCID]
[7] Shah KB, Inoue Y, Mehra MR. Amyloidosis and the heart: A comprehensive review. Archives of Internal Medicine. 2006; 166(17):1805-13. [DOI:10.1001/archinte.166.17.1805] [PMID]
[8] Sucker C, Hetzel GR, Grabensee B, Stockschlaeder M, Scharf RE. Amyloidosis and bleeding: Pathophysiology, diagnosis, and therapy. American Journal of Kidney Diseases. 2006; 47(6):947-55. [DOI:10.1053/j.ajkd.2006.03.036] [PMID]
[9] Caldas CAM, de Carvalho JF. Diagnosis of amyloidosis. Tehran: InTech; 2013. [DOI: 10.5772/52901]
[10] Gameren IIV, Hazenberg BP, Bijzet J, Rijswijk MHV. Diagnostic accuracy of subcutaneous abdominal fat tissue aspiration for detecting systemic amyloidosis and its utility in clinical practice. Arthritis & Rheumatology. 2006; 54(6):2015-21. [DOI:10.1002/art.21902] [PMID]
[11] Tada S, Iwashita A, Matsui T, Fuchigami T, Yamamoto T, Yao T, et al. Endoscopic and biopsy fndings of the upper digestive tract in patients with amyloidosis. Gastrointestinal Endoscopy. 1990; 36(1):10-4. [DOI:10.1016/S0016- 5107(90)70913-3]
[12] Swan N, Skinner M, O’hara CJ. Bone marrow core biopsy specimens in AL (primary) amyloidosis: A morphologic and immunohistochemical study of 100 cases. American Journal of Clinical Pathology. 2003; 120(4):610-6. [DOI:10.1309/ PFUGHBX0TY20E08U] [PMID]
| Files | ||
| Issue | Vol 3 No 3 (2018): Summer | |
| Section | Case Report(s) | |
| Keywords | ||
| Amyloidosis Congo red Duodenal biopsy | ||
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How to Cite
1.
Daraei M, Siri G, Allameh SF, Lotfi M, Alesaeidi S. Amyloidosis With Periorbital Rash. CRCP. 2019;3(3):78-81.
