Scalp Metastasis as an Initial Presentation of Lung Cancer: A Case Report
Introduction: Lung can be affected by various tumors, including lung carcinoma. These tumors exhibit certain clinical signs. In rare cases, they may appear unusual and affect the diagnostic and therapeutic course. Considering the importance of this issue, in the present study, we report a case of lung lymphoma with subsequent lump masses. We report a diagnostic evaluation in a male case with the first manifestation as an unusual presentation of scalp metastasis due to underlying lung cancer. Conclusion: Although lung cancer is typically presented in classical form, it is important to consider unusual manifestations of underlying lung cancer, along with the appearance of scalp lesions.
 Alcaraz I, Cerroni L, Rütten A, Kutzner H, Requena L. Cutaneous metastasis from internal malignancies: A clinicopathologic and immunohistochemical review. The American Journal of Dermatopathology. 2012; 34(4):347-93. [DOI:10.1097/DAD.0b013e31823069cf] [PMID]
 Lee JH, Ahn SJ, Kim HJ, Jang SE, Noh GY, Kim HR, et al. Cutaneous metastasis from lung cancer: A single-institution retrospective analysis. Tuberculosis and Respiratory Diseases. 2011; 70(2):139- 42. [DOI:10.4046/trd.2011.70.2.139]
 Song Z, Lin B, Shao L, Zhang Y. Cutaneous metastasis as an initial presentation in advanced non-small cell lung cancer and its poor survival prognosis. Journal of Cancer Research and Clinical Oncology. 2012; 138(10):1613-7. [DOI:10.1007/s00432-012-1239-6] [PMID]
 Lookingbill DP, Spangler N, Mack Sexton F. Skin involvement as the presenting sign of internal carcinoma. A retrospective study of 7316 cancer patients. Journal of the American Academy of Dermatology. 1990; 22(1):19-26. [DOI:10.1016/0190-9622(90)70002-Y]
 Mollet TW, Garcia CA, Koester G. Skin metastases from lung cancer. Dermatology Online Journal. 2009; 15(5):1. [PMID]
 Molina Garrido MJ, Guillén Ponce C, Soto Martínez JL, Martínez y Sevila C, Carrato Mena A, Moreno Antón F. Cutaneous metastases of lung cancer. Clinical and Translational Oncology. 2006; 8(5):330- 3. [DOI:10.1007/s12094-006-0178-6]
 Hidaka T, Ishii Y, Kitamura S. Clinical features of skin metastasis from lung cancer. Internal Medicine. 1996; 35(6):459-62. [DOI:10.2169/ internalmedicine.35.459] [PMID]
 Kikuchi Y, Matsuyama A, Nomura K. Zosteriform metastatic skin cancer: Report of three cases and review of the literature. Dermatology. 2001; 202(4):336-8. [DOI:10.1159/000051670] [PMID]
 Marcoval J, Moreno A, Peyrí J. Cutaneous infiltration by cancer. Journal of the American Academy of Dermatology. 2007; 57(4):577- 80. [DOI:10.1016/j.jaad.2007.01.034] [PMID]
 Perng DW, Chen CH, Lee YC, Perng RP. Cutaneous metastasis of lung cancer: An ominous prognostic sign. Zhonghua Yi Xue Za Zhi (Taipei). 1996; 57(5):343-7. [PMID]
 Ferrer-Bruker S. The cutaneous manifestations of metastatic lung cancer: Case report and review. Journal of the American Osteopathic College of Dermatology. 2015; 32:34-6.
 Fay T, Henry GC. Correlation of body segmental temperature and its relation to the location of carcinomatous metastasis: Clinical observations and response to methods of refrigeration. Surgery, Gynecology & Obstetrics. 1938; 66:512-24.
 Krathen RA, Orengo IF, Rosen T. Cutaneous metastasis: A metaanalysis of data. Southern Medical Journal. 2003; 96(2):164-7. [DOI:10.1097/01.SMJ.0000053676.73249.E5] [PMID]
 Kall SL, Koblinski JE. Genes that mediate metastasis organotropism. In: Landes Bioscience. Madame Curie Bioscience Database. Texas: Landes Bioscience; 2013.
 Dreizen S, Dhingra HM, Chiuten DF, Umsawasdi T, Valdivieso M. Cutaneous and subcutaneous metastases of lung cancer: Clinical characteristics. Postgraduate Medicine. 1986; 80(8):111-6. [DOI:10 .1080/00325481.1986.11699635] [PMID]
 Browntein MH, Helwig EB. Metastatic tumors of the skin. Cancer. 1972; 29(5):1298-307. [DOI:10.1002/1097- 0142(197205)29:5<1298::aid-cncr2820290526>3.0.co;2-6] [PMID]
 Chiu CS, Lin CY, Kuo TT, Kuan YZ, Chen MJ, Ho HC, et al. Malignant cutaneous tumors of the scalp: A study of demographic characteristics and histologic distributions of 398 Taiwanese patients. Journal of the American Academy of Dermatology. 2007; 56(3):448-52. [DOI:10.1016/j.jaad.2006.08.060] [PMID]
 Farley R, Manolidis S, Ratner D. Adenocarcinoma of the lung metastatic to the skull presenting as a scalp cyst. Journal of the American Academy of Dermatology. 2006; 54(5):916-7. [DOI:10.1016/j. jaad.2006.01.060] [PMID]
 Gupta V, Bhutani N, Marwah N, Sen R. Scalp metastasis as an initial presentation of lung adenocarcinoma: A case report and literature review. International Journal of Surgery Case Reports. 2017; 41:327-31. [DOI:10.1016/j.ijscr.2017.10.060] [PMID] [PMCID]