Tophaceous Gout: An Educatonal Case

  • Anahita Sadeghi 1. Digestive Disease Research Institute, Tehran university of Medical Science, Tehran, Iran
  • Mona Talaschian 2. Internal Medicine department, Tehran university of Medical Science, Tehran, Iran
  • Sudabeh Alatab 3. Digestive Disease Research Center, Digestive Disease Research Institute, Tehran university of Medical Science, Tehran, Iran
Keywords:
Uric acid;, Tophaceous gout;, Colchicine

Abstract

Gout is a type of inflammatory arthritis that results from the deposition of monosodium urate crystals in the articular or periarticular tissues. In this educational case, we report a middle- aged man who presented with multiple nodules distributed bilaterally over the dorsum of his hands, feet, and elbow joints. Based on clinical and histological findings, the nodules were found to be gouty tophi, and the patient was diagnosed with tophaceous gout characterized by collections of solid urates in connective tissues.

References

[1] Forbess LJ, Fields TR. The broad spectrum of urate crystal depositon: Unusual presentatons of gouty tophi. Semin Arthrits Rheum. 2012; 42(2):146-54. [DOI:10.1016/j.semarthrit.2012.03.007] [PMID]
[2] Kumar P, Das A, Savant SS, Mandal RK, Hassan S. Gout nodulosis: Report of a rare case and brief review. Dermatology Online Journal. 2015; 21(1)pii.13030/qt7x98t2jt. [PMID]
[3] Hollingworth P, Scot JT, Burry HC. Nonartcular gout: Hyperuricemia and tophus formaton without gouty arthrits. Arthrits & Rheumatology. 1983; 26(1):98-101. [DOI:10.1002/art.1780260117] [PMID]
[4] Chen JH, Yeh WT, Chuang SY, Wu YY, Pan WH. Gender-specifc risk factors for incident gout: A prospectve cohort study. Journal of Clinical Rheumatology. 2012; 31(2):239-45. [DOI:10.1007/s10067- 011-1802-6] [PMID]
[5] Higgins PA. Gout and pseudogout. Journal of the American Academy of Physician Assistants. 2016; 29(3):50-2. [DOI:10.1097/01. JAA.0000475472.40251.58] [PMID]
[6] Wallace SL, Singer JZ. Therapy in gout. Rheumatc Disease Clinics of North America. 1988; 14(2):441-57. [PMID]
[7] Bolzeta F, Veronese N, Manzato E, Sergi G. Tophaceous gout in the elderly: A clinical case review. Clinical Rheumatology. 2012; 31(7):1127-321. [DOI:10.1007/s10067-012-1956-x] [PMID]
[8] Purohit MB, Purohit TM, Tandon RK. FNAC of gouty tophi--a case report. Indian Journal of Pathology & Microbiology. 2006; 49(1):42-3. [PMID]
[9] Dalbeth N, Kalluru R, Aat O, Horne A, Doyle AJ, McQueen FM. Tendon involvement in the feet of patents with gout: A dual-energy CT study. Annals of the Rheumatc Diseases. 2013; 72(9):1545-8. [DOI:10.1136/annrheumdis-2012-202786] [PMID]
[10] Flores Martn JF, Vázquez Alonso F, Puche Sanz I, Berrio Campos R, Campaña Guterrez MA, Cózar Olmo JM. Gouty tophi in the penis: A case report and review of the literature. Case Reports in Urology. 2012; 2012:594905. [DOI:10.1155/2012/594905] [PMID] [PMCID]
[11] Falasca GF. Metabolic diseases: Gout. Clinical Dermatology. 2006; 24(6):498-508. [DOI:10.1016/j.clindermatol.2006.07.015] [PMID]
[12] Koley S, Salodkar A, Choudhary S, Bhake A, Singhania K, Choudhury M. Tophi as frst manifestaton of gout. Indian Journal of Dermatology, Venereology and Leprology. 2010; 76(4):393-6. [DOI:10.4103/0378-6323.66593] [PMID]
[13] Kasper IR, Juriga MD, Giurini JM, Shmerling RH. Treatment of tophaceous gout: When medicaton is not enough. Seminars in Arthrits and Rheumatsm. 2016; 45(6)669-74. [DOI:10.1016/j.semarthrit.2016.01.005] [PMID]
Published
2019-11-04
How to Cite
1.
Sadeghi A, Talaschian M, Alatab S. Tophaceous Gout: An Educatonal Case. CRCP. 4(3):69-72.
Section
Case Report(s)