Hypercalcemia and Lytic Bone Lesions as a Rare Presentation of Acute Lymphoblastic Leukemia: A Case Report
Abstract
Acute Lymphoblastic Leukemia (ALL) is a type of leukemia that generates from white blood cells in the bone marrow. ALL could present with different nonspecific symptoms. Hypercalcemia is a rare presentation in B-cell ALL. We reported a middle-aged man presented with hypercalcemia and osteolytic bone lesions without bone pain and a definitive diagnosis of B-cell ALL.
[1] Trehan A, Cheetham T, Bailey S. Hypercalcemia in acute lymphoblastic leukemia: An overview. Journal of Pediatric
Hematology/Oncology. 2009; 31(6):424-7. [DOI:10.1097/ MPH.0b013e3181a1c12b] [PMID]
[2] Mahmood K, Ubaid M, Taliya Rizvi S. Multiple osteolytic lesions causing hypercalcemia: A Rare presentation of acute lymphoblastic leukemia. Case Reports in Medicine. 2017; 2017:2347810. [DOI:10.1155/2017/2347810] [PMID] [PMCID]
[3] Alhaj Moustafa M, Seningen JL, Jouni H. Hypercalcemia, renal failure, and skull lytic lesions: Follicular lymphoma masquerading as multiple myeloma. Journal of Investigative Medicine High Impact Case Reports. 2013; 1(2):2324709613486356. [DOI:10.1177/2324709613486356] [PMID] [PMCID]
[4] Narayanan G, Unnikrishnan P, Kumar BS. Hypercalcemia and osteolytic lesion as presenting feature in an adult PH positive acute lymphoblastic leukemia patient mimicking multiple myeloma. European Journal of Pharmaceutical and Medical Research. 2017; 4(3):490-1. https://www.ejpmr.com/home/abstract_id/2173
[5] El-Ashwah S, Eisa N, Denewer M, Essam Y, Atef B, El-Badrawy A, et al. Hypercalcemia with disseminated osteolytic lesions: A rare presentation of adulthood acute lymphoblastic leukemia. Journal of Hematology. 2018; 7(4):154-7. [PMID] [PMCID]
[6] Bechir A, Haifa R, Atef BA, Emna B, Asma A, Nesrine BS, et al. Osteolytic bone lesions, severe hypercalcemia without circulating blasts: Unusual presentation of childhood acute lymphoblastic leukemia. The Pan African Medical Journal. 2017; 26:244. [DOI:10.11604/pamj.2017.26.244.10506] [PMID] [PMCID]
[7] Granacher NCP, Berneman ZN, Schroyens W, Van de Velde ALR, Verlinden A, Gadisseur APA. Adult acute precursor B-cell lymphoblastic leukemia presenting as hypercalcemia and osteolytic bone lesions. Experimental Hematology & Oncology. 2017; 6:9. [DOI:10.1186/s40164-017-0071-8] [PMID] [PMCID]
[8] Zou S, Shen Y, Zhu D, Zhang D, Zhu X. Adult B-cell acute lymphoblastic leukemia dominated by osteolytic bone involvement on CT but less impressive PET on FDG PET/CT images. Clinical Nuclear Medicine. 2017; 42(6):467-70. [DOI:10.1097/ RLU.0000000000001653] [PMID]
[9] Virijevic M, Vidović A, Colović N, Djunić I, Mitrović M, Suvajdzić- Vuković N, et al. Hypercalcemia with multiple osteolytic lesions and increased circulating tumor necrosis factor in an adult patient with B-cell acute lymphoblastic leukemia. Srpski Arhiv za Celokupno Lekarstvo. 2016; 144(3-4):207-10. [DOI:10.2298/ SARH1604207V] [PMID]
[10] Fukasawa H, Kato A, Fujigaki Y, Yonemura K, Furuya R, Hishida A. Hypercalcemia in a patient with B-cell acute lymphoblastic leukemia: A role of proinflammatory cytokine. The American Journal of the Medical Sciences. 2001; 322(2):109-12. [DOI:10.1097/00000441-200108000-00009] [PMID]
[11] Antunovic P, Marisavljevic D, Kraguljac N, Jelusic V. Severe hypercalcemia and extensive osteolytic lesionsin an adult patient with T cell acute lymphoblastic leukemia. Medical Oncology. 1998; 15(1):58-60. [DOI:10.1007/BF02787346] [PMID]
[12] Neupane S, Clines GA, Auchus RJ, Arvan P. Hypercalcemia and osteolytic bone lesions:a surprising etiology. The Endocrine Society’s 97th annual meeting and expo, March 6, 2015. https://endo. confex.com/endo/2015endo/webprogram/Paper19482.html
Hematology/Oncology. 2009; 31(6):424-7. [DOI:10.1097/ MPH.0b013e3181a1c12b] [PMID]
[2] Mahmood K, Ubaid M, Taliya Rizvi S. Multiple osteolytic lesions causing hypercalcemia: A Rare presentation of acute lymphoblastic leukemia. Case Reports in Medicine. 2017; 2017:2347810. [DOI:10.1155/2017/2347810] [PMID] [PMCID]
[3] Alhaj Moustafa M, Seningen JL, Jouni H. Hypercalcemia, renal failure, and skull lytic lesions: Follicular lymphoma masquerading as multiple myeloma. Journal of Investigative Medicine High Impact Case Reports. 2013; 1(2):2324709613486356. [DOI:10.1177/2324709613486356] [PMID] [PMCID]
[4] Narayanan G, Unnikrishnan P, Kumar BS. Hypercalcemia and osteolytic lesion as presenting feature in an adult PH positive acute lymphoblastic leukemia patient mimicking multiple myeloma. European Journal of Pharmaceutical and Medical Research. 2017; 4(3):490-1. https://www.ejpmr.com/home/abstract_id/2173
[5] El-Ashwah S, Eisa N, Denewer M, Essam Y, Atef B, El-Badrawy A, et al. Hypercalcemia with disseminated osteolytic lesions: A rare presentation of adulthood acute lymphoblastic leukemia. Journal of Hematology. 2018; 7(4):154-7. [PMID] [PMCID]
[6] Bechir A, Haifa R, Atef BA, Emna B, Asma A, Nesrine BS, et al. Osteolytic bone lesions, severe hypercalcemia without circulating blasts: Unusual presentation of childhood acute lymphoblastic leukemia. The Pan African Medical Journal. 2017; 26:244. [DOI:10.11604/pamj.2017.26.244.10506] [PMID] [PMCID]
[7] Granacher NCP, Berneman ZN, Schroyens W, Van de Velde ALR, Verlinden A, Gadisseur APA. Adult acute precursor B-cell lymphoblastic leukemia presenting as hypercalcemia and osteolytic bone lesions. Experimental Hematology & Oncology. 2017; 6:9. [DOI:10.1186/s40164-017-0071-8] [PMID] [PMCID]
[8] Zou S, Shen Y, Zhu D, Zhang D, Zhu X. Adult B-cell acute lymphoblastic leukemia dominated by osteolytic bone involvement on CT but less impressive PET on FDG PET/CT images. Clinical Nuclear Medicine. 2017; 42(6):467-70. [DOI:10.1097/ RLU.0000000000001653] [PMID]
[9] Virijevic M, Vidović A, Colović N, Djunić I, Mitrović M, Suvajdzić- Vuković N, et al. Hypercalcemia with multiple osteolytic lesions and increased circulating tumor necrosis factor in an adult patient with B-cell acute lymphoblastic leukemia. Srpski Arhiv za Celokupno Lekarstvo. 2016; 144(3-4):207-10. [DOI:10.2298/ SARH1604207V] [PMID]
[10] Fukasawa H, Kato A, Fujigaki Y, Yonemura K, Furuya R, Hishida A. Hypercalcemia in a patient with B-cell acute lymphoblastic leukemia: A role of proinflammatory cytokine. The American Journal of the Medical Sciences. 2001; 322(2):109-12. [DOI:10.1097/00000441-200108000-00009] [PMID]
[11] Antunovic P, Marisavljevic D, Kraguljac N, Jelusic V. Severe hypercalcemia and extensive osteolytic lesionsin an adult patient with T cell acute lymphoblastic leukemia. Medical Oncology. 1998; 15(1):58-60. [DOI:10.1007/BF02787346] [PMID]
[12] Neupane S, Clines GA, Auchus RJ, Arvan P. Hypercalcemia and osteolytic bone lesions:a surprising etiology. The Endocrine Society’s 97th annual meeting and expo, March 6, 2015. https://endo. confex.com/endo/2015endo/webprogram/Paper19482.html
| Files | ||
| Issue | Vol 5 No 2 (2020): Spring | |
| Section | Case Report(s) | |
| DOI | https://doi.org/10.18502/crcp.v5i2.3840 | |
| Keywords | ||
| Leukemia Hypercalcemia Bone marrow examination | ||
| Rights and permissions | |
|
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
How to Cite
1.
Mouodi M, Rabizadeh S, Jalaeikhoo H, Nakhjavani M. Hypercalcemia and Lytic Bone Lesions as a Rare Presentation of Acute Lymphoblastic Leukemia: A Case Report. CRCP. 2020;5(2):47-50.
