Hydroxychloroquine-Induced Hyperpigmentation: A Case Report
,
Abstract
Antimalarial agents, including chloroquine and hydroxychloroquine, have been used for the treatment of various rheumatoid diseases and skin diseases because of their anti-inflammatory and immune-modulating properties. Cutaneous adverse effects such as exacerbation of psoriasis, pruritus, and hyperpigmentation have been reported as side-effects of antimalarial drugs. In this case, we report a middle-aged man with a history of rheumatoid arthritis who was treated with non-steroidal anti-inflammatory drugs and hydroxychloroquine. He complained of hyperpigmentation of the face after one year of initiating the hydroxychloroquine. It was discontinued and methotrexate was started. Skin biopsy was confirmed drug reaction. After more than 10 years of follow up, his skin discoloration had not been improved.
[2] Veraldi S, Schianchi-Veraldi R, Scarabelli G. Pigmentation of the gums following hydroxychloroquine therapy. Cutis. 1992; 49(4):281-2. [PMID]
[3] Jallouli M, Francès C, Piette J C, Moguelet P, Factor C, Zahr N, et al. Hydroxychloroquine-induced pigmentation in patients with systemic lupus erythematosus: A case-control study. JAMA Dermatology. 2013; 149(8):935-40. [DOI:10.1001/jamadermatol.2013.709] [PMID]
[4] Rood MJ, Vermeer MH, Huizinga TW. Hyperpigmentation of the skin due to hydroxychloroquine. Scandinavian Journal of Rheumatology. 2008; 37:158. [DOI:10.1080/03009740701769735] [PMID]
[5] Amichai B, Gat A, Grunwald MH. Cutaneous hyperpigmentation during therapy with hydroxychloroquine. Journal of
Clinical Rheumatology. 2007; 13(2):113. [ DOI:10.1097/01. rhu.0000260649.36417.09] [PMID]
[6] Puri PK, Lountzis NI, Tyler W, Ferringer T. Hydroxychloroquine‐induced hyperpigmentation: The staining pattern. Journal of Cutaneous Pathology. 2008; 35(12):1134-7. [ DOI:10.1111/j.1600- 0560.2008.01004.x] [PMID]
[7] Tracy CL, Blakey B, Parker G, Roebuck J. Hydroxychloroquine-induced hyperpigmentation. Journal of Clinical Rheumatology. 2013; 19(5):292. [DOI:10.1097/RHU.0b013e31829d547b] [PMID]
[8] Tuffanelli D, Abraham RK, Dubois EI. Pigmentation from antimalarial therapy: Its possible relationship to the ocular lesions. Archives of Dermatology. 1963; 88(4):419-26. [DOI:10.1001/arch- derm.1963.01590220051006] [PMID]
[9] Kasper RS, Flueckiger B, Gobbi S, Lautenschlager S, Borelli S. Hydroxychloroquine‐induced hyperpigmentation. Journal of Deutschen Dermatologischen Gesellschaft. 2014; 12(2):158-61. [DOI:10.1111/ddg.12232] [PMID]
| Files | ||
| Issue | Vol 5 No 3 (2020): Summer | |
| Section | Case Report(s) | |
| DOI | https://doi.org/10.18502/crcp.v5i3.4364 | |
| Keywords | ||
| Hydroxychloroquine Hyperpigmentation Drug side effect Rheumatoid arthritis | ||
| Rights and permissions | |
|
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
