Metastatc Gastric Adenocarcinoma Cancer With a Very High Serum Carbohydrate Antgen 19-9 Level: A Case Study
Abstract
Carbohydrate Antigen 19-9 (CA19-9) is a tumor marker for the prognosis of colorectal and pancreatic cancers. The high level of this tumor marker in gastric cancer indicates the advanced stage and peritoneal metastasis of the tumor. We reported a case of gastric cancer with an extremely high serum level of CA19-9. We also measured the serum levels of carcinoembryonic antigen and Carbohydrate Antigen 125 in the reported case. Such tumor markers manifest the progression and poor prognosis of cancer. Computed tomography data indicated several lytic and sclerotic foci in the inferior thoracic, lumbar vertebrae, and the right iliac wing, along with invasion to lymph nodes and a right adnexal mass in the reported patient. Bone marrow biopsy results revealed that carcinoma cells were predominantly composed of signet ring cell carcinoma. The patient has expired before receiving any interventions for cancer.
[2] Liang Y, Wang W, Fang C, Raj SS, Hu W-M, Li Q-W, et al. Clinical signifcance and diagnostc value of serum CEA, CA19-9 and CA72- 4 in patents with gastric cancer. Oncotarget. 2016; 7(31):49565. [DOI:10.18632/oncotarget.10391] [PMID] [PMCID]
[3] Sawayama H, Iwatsuki M, Kuroda D, Toihata T, Uchihara T, Koga Y, et al. The associaton of the lymph node rato and serum Carbohydrate Antgen 19-9 with early recurrence afer curatve gastrectomy for gastric cancer. Surgery Today. 2018; 48(11):994-1003. [DOI:10.1007/s00595-018-1684-1] [PMID]
[4] Song YX, Huang XZ, Gao P, Sun JX, Chen XW, Yang YC, et al. Clinicopathologic and prognostc value of serum Carbohydrate Antgen 19-9 in gastric cancer: A meta-analysis. Disease Markers. 2015; 2015:549843. [DOI:10.1155/2015/549843] [PMID] [PMCID]
[5] Wu D, Zhang P, Ma J, Xu J, Yang L, Xu W, et al. Serum biomarker panels for the diagnosis of gastric cancer. Cancer Medicine. 2019; 8(4):1576-83. [DOI:10.1002/cam4.2055] [PMID] [PMCID]
[6] Ghaderi B, Moghbel H, Daneshkhah N, Babahajian A, Sheikhesmaeili F. Clinical evaluaton of serum tumor markers in the diagnosis of gastric adenocarcinoma staging and grading. Journal of Gastrointestnal Cancer. 2019; 50(3):525-9. [DOI:10.1007/s12029-018-0091-6] [PMID]
[7] Kotzev AI, Draganov PV. Carbohydrate Antgen 19-9, carcinoembryonic antgen, and Carbohydrate Antgen 72-4 in gastric cancer: Is the old band stll playing? Gastrointest Tumors. 2018; 5(1-2):1-13.
[DOI:10.1159/000488240] [PMID] [PMCID]
[8] Thakur V, Mukherjee U. Unusually high serum CA19. 9 in gastric carcinoma: A case report. Indian Journal of Clinical Biochemistry: IJCB. 2008; 23(1):100-2. [DOI:10.1007/s12291-008-0025-3] [PMID] [PMCID]
[9] Wang W, Chen XL, Zhao SY, Xu YH, Zhang WH, Liu K, et al. Prognostc signifcance of preoperatve serum CA125, CA19-9 and CEA in gastric carcinoma. Oncotarget. 2016; 7(23):35423. [DOI:10.18632/ oncotarget.8770] [PMID] [PMCID]
[10] Feng F, Tian Y, Xu G, Liu Z, Liu S, Zheng G, et al. Diagnostc and prognostc value of CEA, CA19-9, AFP and CA125 for early gastric cancer. BMC Cancer. 2017; 17(1):737. [DOI:10.1186/s12885-017- 3738-y] [PMID] [PMCID]
[11] Liu X, Meng X, Li Y, Chai W, Qian J, Tang H. Role of CA19-9 in the prognostc evaluaton of SOX neoadjuvant chemotherapy for gastric cancer. Internatonal Journal of Clinical and Experimental Pathology. 2018; 11(11):5387-93. [PMID] [PMCID]
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| Issue | Vol 6 No 1 (2021): January-February | |
| Section | Case Report(s) | |
| DOI | https://doi.org/10.18502/crcp.v6i1.5956 | |
| Keywords | ||
| Gastric adenocarcinoma Tumor marker Carbohydrate antgen 19-9 (CA-19-9) | ||
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
