Case Report

Burkitt’s Lymphoma of Intestine Presenting as Ileocolic Intussusception


Burkitt lymphoma, as the most common non-Hodgkin Bcell lymphoma of childhood, is rarely detected in the gastrointestinal tract. Intussusception secondary to Burkitt’s lymphoma is an uncommon presentation. We describe an unusual case of intestinal Burkitt’s lymphoma in a four and the half-year-old girl who presented with intermittent colicky pain three times. Imaging studies were suggestive of intussusception. The patient was subjected to the surgery of bowel resection, which revealed a creamy-gray oval-shaped mass. Histopathology through immunohistochemistry study confirmed the Burkitt lymphoma. Owing to rather nonspecific clinical and radiological features, the preoperative diagnosis of Burkitt lymphoma remains a challenging task for pediatric surgeons and radiologists. Therefore, in case of any clinical suspicion, further examinations, such as CT scan in children are recommended.

[1] Senbanjo IO. Tumor lysis and acute renal failure in Burkitt’s lymphoma: A review on pathophysiology and management. Indian Journal of Nephrology. 2009; 19(3):83-6. [DOI:10.4103/0971-4065.57102]
[2] Bishop PC, Rao VK, Wilson WH. Burkitt’s lymphoma: Molecular pathogenesis and treatment. Cancer Investigation. 2000; 18(6):574-83. [DOI:10.3109/07357900009012197] [PMID]
[3] Takahashi H, Hansmann ML. Primary gastrointestinal lymphoma in childhood (up to 18 years of age). Journal of Cancer Research and Clinical Oncology. 1990; 116(2):190-6. [DOI:10.1007/BF01612676] [PMID]
[4] Hoxha FT, Hashani SI, Krasniqi AS, Kurshumliu FI, Komoni DS, Hasimja SM, Maxhuni M. Intussusceptions as acute abdomen caused by Burkitt lymphoma: A case report. Cases Journal. 2009; 2(9322):1-6. [DOI:10.1186/1757-1626-2 9322] [PMID] [PMCID]
[5] Attarbaschi A, Mann G, Dworzak M, Trebo M, Mühlegger N, Reiter A, et al. The role of surgery in the treatment of pediatric Bcell non-Hodgkin’s lymphoma. Journal of Pediatric Surgery. 2002; 37(10):1470-5. [DOI:10.1053/jpsu.2002.35417] [PMID]
[6] Sharma P, Zaheer M, Chowdury S, Mandal KA. Burkitt’s lymphoma of intestine presenting as ileocolic intussusception: An atypical presentation. International Journal of Health & Allied Sciences. 2018; 7(3):207-9. [DOI:10.4103/ijhas.IJHAS_86_17]
[7] Gupta H, Davidoff AM, Pui CH, Shochat SJ, Sandlund JT. Clinical implications and surgical management of intussusception in pediatric patients with Burkitt lymphoma. Journal of Pediatric Surgery. 2007; 42(6):998-1001. [DOI:10.1016/j.jpedsurg.2007.01.033] [PMID]
[8] Blakelock RT, Beasley SW. The clinical implications of non-idiopathic intussusception. Pediatric Surgery International. 1998; 14(3):163-7. [DOI:10.1007/s003830050475] [PMID]
[9] Burkitt D. A sarcoma involving the jaws in African children. The British Journal of Surgery. 1958; 46(197):218-23. [DOI:10.1002/ bjs.18004619704] [PMID]
[10] Wang SM, Huang FC, Wu CH, Ko SF, Lee SW, Hsiao CC. Ileocecal Burkitt’s lymphoma presenting as ileocolic intussusception with appendiceal invagination and acute appendicitis. Journal of the Formosan Medical Association. 2010; 109(6):476-9. [DOI:10.1016/ S0929-6646(10)60080-0]
[11] Kulendran K, Choy KT, Keogh C, Ratnapala D. An exceptional case of ileocolic intussusception secondary to Burkitt’s lymphoma: What variations are there in the presentation and management of those
patients who approach adolescence? Case Reports in Surgery. 2018; 2018:6251321. [DOI:10.1155/2018/6251321] [PMID] [PMCID]
[12] Sorantin E, Lindbichler F. Management of intussusception. European Radiology. 2004; (Suppl 4):L146-54. [DOI:10.1007/s00330- 003-2033-2] [PMID]
[13] Gahukamble DB, Khamage AS. Limitations of surgery in intraabdominal Burkitt’s lymphoma in children. Journal of Pediatric Surgery. 1995; 30(4):519-22. [DOI:10.1016/0022-3468(95)90121-3]
[14] Grajo JR, Kayton ML, Steffenson TS, Dragicevic N, Guidi CB. Presentation of ileal Burkitt lymphoma in children. Journal of Radiology Case Reports. 2012; 6(8):27-38. [DOI:10.3941/jrcr.v6i8.1052] [PMID] [PMCID]
IssueVol 6 No 2 (2021): Mar/Apr QRcode
SectionCase Report(s)
Burkitt’s lymphoma Intestine Intussusception

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
How to Cite
Jafar Aghaie M, Dehghani Zahedani M. Burkitt’s Lymphoma of Intestine Presenting as Ileocolic Intussusception. CRCP. 2021;6(2):70-73.